Human Endogenous Retrovirus-H-Derived miR-4454 Inhibits the Expression of DNAJB4 and SASH1 in Non-Muscle-Invasive Bladder Cancer

Although most human endogenous retroviruses (HERVs) have been silenced and lost their ability to translocate because of accumulated mutations during evolution, they still play important roles in biology. Several studies demonstrated that HERVs pathological numerous diseases, especially cancer. A few revealed long non-coding RNAs are transcribed from HERV sequences affect cancer progression. However, there is no study on microRNAs derived related In this study, we identified 29 (miRNAs) the genome. particular, discovered miR-4454, which HERV-H-derived miRNA, was upregulated non-muscle-invasive bladder (NMIBC) cells. To figure out effects miR-4454 NMIBC, genes whose expression downregulated as well tumor suppressor genes, were selected putative target miR-4454. The dual-luciferase assay used determine negative relationship between its DNAJB4 SASH1, confirmed be promising Taken together, suggests upregulation HERV-H NMIBC reduces promote